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Female Reproductive System and Breast 301 tab 19-2 Abbreviated List of Histologic Types of Carcinoma of the Breast Types Characteristics Intraductal carcinoma in situ Tumor cells fill ducts; tumor cell necrosis results in a cheese-like consistency (comedocarcinoma) Invasive ductal carcinoma Most frequent kind; characterized by tumor cells organized in cords, islands, and (scirrhous carcinoma) glands embedded in a dense fibrous stroma; plentiful fibrous tissue ends in firm consistency Paget disease of the breast Eczematoid lesion of the nipple or areola; neoplastic Paget cells, attribute massive cells surrounded by a transparent halo-like area, invade the epidermis; underlying ductal carcinoma almost all the time current Lobular carcinoma in situ Clusters of neoplastic cells fill intralobular ductules and acini; could result in invasive carcinoma (often a few years later) in the identical or within the contralateral breast; usually bilateral at the time of the preliminary prognosis Invasive lobular carcinoma Often multicentric or bilateral; tends to have cells organized in a linear trend ("Indian­ file" look); higher prognosis than that for invasive ductal carcinoma Medullary carcinoma Cellular with scant stroma; sof, fleshy consistency; characteristic lymphocytic infiltrate; prognosis higher than that for invasive ductal carcinoma Mucinous (colloid) carcinoma Pools of extracellular mucus surrounding clusters of tumor cells; gelatinous consistency; prognosis better than that for invasive ductal carcinoma Inflammatory carcinomas Lymphatic involvement of pores and skin by underlying carcinoma, inflicting pink, swollen, sizzling pores and skin resembling an inflammatory process; poor prognosis (three) History of breast most cancers in a single breast: associated with increased incidence in the opposite breast (4) Early menarche and late menopause: could also be as a result of increased duration of repro ductive life and related hormonal exercise (5) Obesity: presumably due to manufacturing of estrogens by adipose tissue (6) Nulliparity (7) First being pregnant after 30 years of age (8) Diet high in animal fats: incidence is five occasions larger in the United States than in Japan (9) Proliferative fibrocystic disease with atypical epithelial hyperplasia Review Test Directions: Each ofthe numbered objects or incomplete statements on this section is adopted by solutions or by completions ofthe statement. 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